A Model System for Increased Meiotic Nondisjunction in Older Oocytes

@article{Jeffreys2003AMS,
  title={A Model System for Increased Meiotic Nondisjunction in Older Oocytes},
  author={Charlotte A Jeffreys and Peter S. Burrage and Sharon E. Bickel},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={498-503}
}
For at least 5% of all clinically recognized human pregnancies, meiotic segregation errors give rise to zygotes with the wrong number of chromosomes. Although most aneuploid fetuses perish in utero, trisomy in liveborns is the leading cause of mental retardation. A large percentage of human trisomies originate from segregation errors during female meiosis I; such errors increase in frequency with maternal age. Despite the clinical importance of age-dependent nondisjunction in humans, the… CONTINUE READING
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