A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly

@article{Tsai2006AML,
  title={A Mitotic Lamin B Matrix Induced by RanGTP Required for Spindle Assembly},
  author={M. Tsai and Shusheng Wang and Jill M Heidinger and D. Shumaker and S. Adam and R. Goldman and Y. Zheng},
  journal={Science},
  year={2006},
  volume={311},
  pages={1887 - 1893}
}
Mitotic spindle morphogenesis is a series of highly coordinated movements that lead to chromosome segregation and cytokinesis. We report that the intermediate filament protein lamin B, a component of the interphase nuclear lamina, functions in spindle assembly. Lamin B assembled into a matrix-like network in mitosis through a process that depended on the presence of the guanosine triphosphate–bound form of the small guanosine triphosphatase Ran. Depletion of lamin B resulted in defects in… Expand
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