A Mitochondrial Protein, Bit1, Mediates Apoptosis Regulated by Integrins and Groucho/TLE Corepressors

@article{Jan2004AMP,
  title={A Mitochondrial Protein, Bit1, Mediates Apoptosis Regulated by Integrins and Groucho/TLE Corepressors},
  author={Yiwen Jan and Michelle L Matter and Jih-tung Pai and Y Chen and Jan Pilch and Masanobu Komatsu and Edgar Ong and Minoru Fukuda and Erkki Ruoslahti},
  journal={Cell},
  year={2004},
  volume={122},
  pages={485-486}
}
A delicate balance of signals regulates cell survival. One set of these signals is derived from integrin-mediated cell adhesion to the extracellular matrix (ECM). Loss of cell attachment to the ECM causes apoptosis, a process known as anoikis. In searching for proteins involved in cell adhesion-dependent regulation of anoikis, we identified Bit1, a mitochondrial protein that is released into the cytoplasm during apoptosis. Cytoplasmic Bit1 forms a complex with AES, a small Groucho/transducin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 69 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Cell detachControl of adhesiondependent cell survival by focal adhesion kiment triggers p 38 mitogen - activated protein kinasedependentnase

  • K. Rosen, W. Shi, B. Calabretta, J. Filmus
  • J . Cell Biol .
  • 2002
1 Excerpt

Enhancer of split complex

  • T. R. Brummelkamp, R. Bernards, R. Agami
  • Dev . Dyn .
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…