A Miniature Low-Power Multi-Biomarker-Based Brain Sensor for Closed-Loop DBS

@article{Parastarfeizabadi2017AML,
  title={A Miniature Low-Power Multi-Biomarker-Based Brain Sensor for Closed-Loop DBS},
  author={Mahboubeh Parastarfeizabadi and Abbas Z. Kouzani},
  journal={IEEE Sensors Journal},
  year={2017},
  volume={17},
  pages={3109-3115}
}
Thus far only a few closed-loop deep brain stimulation (DBS) devices have been developed. These devices measure one biomarker for closing the stimulation loop. However, there are many types of neurological disorders requiring different biomarkers to be monitored. Therefore, a multiple-biomarker-based neural sensing device is needed to achieve closed-loop DBS for multiple disorders. This paper presents the design, fabrication, and in vitro evaluation of a miniature multi-biomarker-based neural… 

Figures and Tables from this paper

A Miniature Dual-Biomarker-Based Sensing and Conditioning Device for Closed-Loop DBS
TLDR
The dual-biomarker-based neural sensing and conditioning device can be used to concurrently sense LFPs and APs for closing the feedback loop in closed-loop deep brain stimulation systems and provides a tetherless head-mountable platform suitable for pre-clinical trials.
A Programmable Multi-Biomarker Neural Sensor for Closed-Loop DBS
TLDR
The design, fabrication, and validation of a programmable multi-biomarker neural sensor which can be integrated into closed-loop DBS devices and enable tetherless back-mountable use in pre-clinical trials is presented.
Multi-Disease Deep Brain Stimulation
TLDR
The design and evaluation of a multi-disease closed-loop DBS device that can sense multiple brain biomarkers, detect a disorder, and adaptively deliver electrical stimulation pulses based on the disease state is presented.
Advances in closed-loop deep brain stimulation devices
TLDR
The promising clinical effects of open-loop DBS have been demonstrated, indicating DBS as a pioneer technology and treatment option to serve neurological patients, however, like other commercial devices, DBS needs to be automated and modernized.
An Adaptive LFP Sensor
TLDR
The design of an adaptive gain-adjustable LFP sensing device that can cope with a wide range of LFP signal amplitude variations over different individuals, or over long-term chronic use in one specific subject is proposed.
Closed-Loop Deep Brain Stimulation
This work aims at providing a wide overview of different approaches of Brain Medical Stimulation dedicated to patients afflicted by severe disabling diseases like Parkinson, dystonia,

References

SHOWING 1-10 OF 32 REFERENCES
A miniature closed-loop deep brain stimulation device
TLDR
A miniature light-weight closed-loop deep brain stimulation (DBS) device that delivers on-demand stimulation current pulses by monitoring and analysing local field potentials and has been successfully validated by injecting a pre-recorded neural signal into its input, and collecting and analysed its output.
A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management
TLDR
A logarithmic, closed-loop DBS system that detects and processes low-frequency brain field signals to control and adapt stimulation currents and achieves high dynamic range is introduced.
Development of the Mayo Investigational Neuromodulation Control System: toward a closed-loop electrochemical feedback system for deep brain stimulation.
TLDR
A series of proof-of-principle tests in the rat brain demonstrating MINCS to be a reliable and flexible stimulation device that, when used in conjunction with WINCS, performs wirelessly controlled stimulation concurrent with artifact-free neurochemical recording is reported.
Implantable neurotechnologies: a review of integrated circuit neural amplifiers
TLDR
This review focuses on neural amplifier-based devices and is presented in two interrelated parts, highlighting applications of IC-based neural amplifiers in basic science experiments, neural prostheses, and treatment of neuronal diseases.
Design and Validation of a Fully Implantable, Chronic, Closed-Loop Neuromodulation Device With Concurrent Sensing and Stimulation
TLDR
Systematic methods to mitigate the effect of stimulation through a combination of sensing hardware, stimulation parameter selection, and classification algorithms that counter residual stimulation disturbances are described.
Enabling Low-Power, Multi-Modal Neural Interfaces Through a Common, Low-Bandwidth Feature Space
TLDR
The Multi-modal Implantable Neural Interface (MINI), a wireless recording system which extracts and transmits signal power in a single, configurable frequency band, is designed and tested and believes this system architecture can be used to produce a viable, cost-effective, clinical BMI.
Miniature wireless recording and stimulation system for rodent behavioural testing.
TLDR
A miniature wireless system developed for rodent use that combined multichannel DBS and local-field potential (LFP) recordings and could be wirelessly activated/deactivated at any part of the experiment during EEG recording and transmission, allowing for a seamless integration of this modality.
Development of wireless neural interface system
TLDR
The proposed wireless neural interface system (WNIS) that is capable of multi-channel recording and stimulation with a wireless charging battery was successfully applied to wireless neural signal acquisitions and neuromodulations.
A Battery-Powered Activity-Dependent Intracortical Microstimulation IC for Brain-Machine-Brain Interface
This paper describes an activity-dependent intracortical microstimulation (ICMS) system-on-chip (SoC) that converts extracellular neural spikes recorded from one brain region to electrical stimuli
...
1
2
3
4
...