A Miniature Dual-Biomarker-Based Sensing and Conditioning Device for Closed-Loop DBS

  title={A Miniature Dual-Biomarker-Based Sensing and Conditioning Device for Closed-Loop DBS},
  author={Mahboubeh Parastarfeizabadi and Abbas Z. Kouzani},
  journal={IEEE Journal of Translational Engineering in Health and Medicine},
In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two channels, each having four main parts: (1) a pre-amplifier with built-in low-pass filter, (2) a ground shifting circuit, (3) an amplifier with low-pass function, and (4) a high-pass filter. The design specifications… 
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