A Method for Functional Trans-Complementation of Intracellular Francisella tularensis

@inproceedings{Steele2014AMF,
  title={A Method for Functional Trans-Complementation of Intracellular Francisella tularensis},
  author={Shaun P Steele and Sharon A. Taft-Benz and Thomas H Kawula},
  booktitle={PloS one},
  year={2014}
}
Francisella tularensis is a highly infectious bacterial pathogen that invades and replicates within numerous host cell types. After uptake, F. tularensis bacteria escape the phagosome, replicate within the cytosol, and suppress cytokine responses. However, the mechanisms employed by F. tularensis to thrive within host cells are mostly unknown. Potential F. tularensis mutants involved in host-pathogen interactions are typically discovered by negative selection screens for intracellular… CONTINUE READING
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