Microneedles, before being used for biomedical applications, have to satisfy biological and technical specifications, in particular they must guarantee a sufficient strength during exercise. Although studies on the mechanical characterization on single microneedles are reported in literature, microneedles must be arranged in matrices to be used in real biomedical applications. For these reasons, it is necessary to define a margin of safety for complete arrays of microneedles. In this study forces required to pierce human skin, by means of piercing tests, and maximum forces which arrays can withstand without breaking, through compressive tests, are carried out to determine a preliminary margin of safety for microneedles arrays. Index Terms – array, mechanical characterization, microneedles.