A Metabolic Basis for Alzheimer Disease

Abstract

Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.

DOI: 10.1023/A:1025678510480

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@article{Perry2003AMB, title={A Metabolic Basis for Alzheimer Disease}, author={George Perry and Akihiko Nunomura and A. K. Raina and Gjumrakch Aliev and Sandra Siedlak and Peggy L. R. Harris and Gemma Casades{\'u}s and Robert Bob Petersen and William Z Bligh-Glover and Elizabeth K Balraj and G. J. Petot and Mark A. Smith}, journal={Neurochemical Research}, year={2003}, volume={28}, pages={1549-1552} }