A Meta-Analysis of Cytokines in Major Depression
@article{Dowlati2010AMO, title={A Meta-Analysis of Cytokines in Major Depression}, author={Yekta Dowlati and Nathan Herrmann and Walter Swardfager and Helena Liu and Lauren Sham and Elyse Reim and Krista L. Lanct{\^o}t}, journal={Biological Psychiatry}, year={2010}, volume={67}, pages={446-457} }
3,497 Citations
The role of interleukin genes in the course of depression
- Medicine, PsychologyOpen medicine
- 2016
There is no significant difference in IL-1, IL-6 and IL-10 expression between patients with recurrent depressive disorders and those suffering from the first episode of depression, according to the mRNA and protein levels of three interleukins.
Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis
- Psychology, BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
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Inflammatory cytokines in major depressive disorder: A case–control study
- Medicine, PsychologyThe Australian and New Zealand journal of psychiatry
- 2017
The heterogeneity of major depressive disorder, as well as a potential sampling bias selecting for non-inflammatory depression, might have determined the findings discordant with the literature.
Peripheral cytokine and chemokine alterations in depression: an up-dated meta-analysis of 82 studies
- Biology, Medicine
- 2017
A systematic review and meta-analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs) further characterize a cytokine/chemokine profile associated with MDD.
Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder
- Psychology, MedicinePsychiatry investigation
- 2013
The present study does not support a potential involvement of IL-23 and IL-17 axis in major depression, and replication and extension using a larger sample are required.
The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
- Psychology, BiologyNeuropsychopharmacology
- 2011
Overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNFα, but antidepressant treatment did reduce levels of IL-1β and possibly those ofIL-6, which are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects ofinflammatory cytokines on the brain.
Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
- Biology, PsychologyPloS one
- 2018
Evidence of changes in cytokine levels in antidepressant drug-naïve patients with MDD is presented, finding linear correlations between IL-1β, TNF-α, and IL-8, and the severity of depression, as well as betweenIL-8 and anxiety level in patients with comorbid anxiety disorder.
A meta-analysis of chemokines in major depression
- BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2016
The predictive value of somatic and cognitive depressive symptoms for cytokine changes in patients with major depression
- Psychology, MedicineNeuropsychiatric disease and treatment
- 2014
It is demonstrated that a history of somatoform symptoms may be important for predicting future changes in TNF-alpha in women with major depression.
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
- Biology, PsychologyJournal of neuroinflammation
- 2021
An integrated account of how IL-6 may contribute to development of depression is provided to prevent further escalation of inflammatory responses, and potentially pave the way for opening new avenues in diagnosis, treatment, and prevention of this debilitating disorder.
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