A Meta-Analysis of Cytokines in Major Depression

  title={A Meta-Analysis of Cytokines in Major Depression},
  author={Yekta Dowlati and Nathan Herrmann and Walter Swardfager and Helena Liu and Lauren Sham and Elyse Reim and Krista L. Lanct{\^o}t},
  journal={Biological Psychiatry},
The role of interleukin genes in the course of depression
There is no significant difference in IL-1, IL-6 and IL-10 expression between patients with recurrent depressive disorders and those suffering from the first episode of depression, according to the mRNA and protein levels of three interleukins.
Effect of antidepressant treatment on peripheral inflammation markers – A meta-analysis
Inflammatory cytokines in major depressive disorder: A case–control study
The heterogeneity of major depressive disorder, as well as a potential sampling bias selecting for non-inflammatory depression, might have determined the findings discordant with the literature.
Peripheral cytokine and chemokine alterations in depression: an up-dated meta-analysis of 82 studies
A systematic review and meta-analysis of studies that measured cytokine and chemokine levels in individuals with major depressive disorder (MDD) compared to healthy controls (HCs) further characterize a cytokine/chemokine profile associated with MDD.
Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder
The present study does not support a potential involvement of IL-23 and IL-17 axis in major depression, and replication and extension using a larger sample are required.
The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis
Overall, while pharmacological antidepressant treatment reduced depressive symptoms, it did not reduce serum levels of TNFα, but antidepressant treatment did reduce levels of IL-1β and possibly those ofIL-6, which are consistent with the possibility that inflammatory cytokines contribute to depressive symptoms and that antidepressants block the effects ofinflammatory cytokines on the brain.
Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression
Evidence of changes in cytokine levels in antidepressant drug-naïve patients with MDD is presented, finding linear correlations between IL-1β, TNF-α, and IL-8, and the severity of depression, as well as betweenIL-8 and anxiety level in patients with comorbid anxiety disorder.
A meta-analysis of chemokines in major depression
  • H. EyreT. Air B. Baune
  • Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2016
The predictive value of somatic and cognitive depressive symptoms for cytokine changes in patients with major depression
It is demonstrated that a history of somatoform symptoms may be important for predicting future changes in TNF-alpha in women with major depression.
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
An integrated account of how IL-6 may contribute to development of depression is provided to prevent further escalation of inflammatory responses, and potentially pave the way for opening new avenues in diagnosis, treatment, and prevention of this debilitating disorder.


Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
The hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients is supported.
Indicators of immune activation in major depression
Increase in interleukin-1beta in late-life depression.
These findings support the existence of an inflammatory response, which may be state dependent, in late-life depression.
Assessment of the immune system activity in Iranian patients with Major Depression Disorder (MDD).
Investigation of changes in immunoglobulin and cytokine serum levels and lymphocyte subsets in patients with major depressed patients found no significant differences in immune system activity.
Increase in interleukin-1 beta in late-life depression
The authors tested the hypothesis that levels of cytokine interleukin-1β (IL-1 β) would be higher in subjects with late-life major depression, and found that those with major depression had significantly higher levels of IL-1α, which is strongly correlated with current depression severity.
Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission.
Serum IL-6, IL-10,IL-1Ra levels were higher in the subjects with major depression than in normal controls although these results were not statistically significant, and the mean score according to the Hamilton Depression Rating Scale in the patients significantly decreased during the 6 weeks of the study, demonstrating an overall improvement.
Plasma Concentrations of Interleukin-1β, Interleukin-6, Soluble Interleukin-2 Receptor and Tumor Necrosis Factor α of Depressed Patients in Japan
It is suggested that the plasma sIL-2R concentration is associated with mood state, and that the Plasma TNF-α concentration is increased after pharmacotherapy in Japanese depressed patients.