A Meta-Analysis of Cytokines in Alzheimer's Disease

@article{Swardfager2010AMO,
  title={A Meta-Analysis of Cytokines in Alzheimer's Disease},
  author={Walter Swardfager and Krista L. Lanct{\^o}t and Lana S. Rothenburg and A. Wong and Jaclyn Cappell and Nathan Herrmann},
  journal={Biological Psychiatry},
  year={2010},
  volume={68},
  pages={930-941}
}
Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies
TLDR
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TLDR
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TLDR
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TLDR
Plasma levels of IL-6 and TRAIL were identified as potential biomarkers of AD at an early stage and were significantly correlated with their cerebrospinal fluid levels.
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TLDR
The findings do not support the involvement of inflammatory markers at the MCI stage of cognitive decline although significant heterogeneity was observed in some comparisons.
Raised serum proinflammatory cytokines in Alzheimer's disease with depression.
TLDR
A strong inverse correlation was observed between the MMSE scores and serum levels of IL-6 or TNF-α in AD subjects with depression and an important role is highlighted in AD associated depression and cognitive deficits.
Plasma Cytokines Profile in Subjects with Alzheimer’s Disease: Interleukin 1 Alpha as a Candidate for Target Therapy
TLDR
Based on the observed correlation between IL-1α, as a clinical moiety, and ADAS-cog, as an clinical manifestation of AD, anti-IL-1 α therapy in AD could be suggested.
Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease: A Systematic Review and Meta-analysis.
TLDR
The findings of the meta-analysis demonstrated higher peripheral concentrations of IL-6, tumor necrosis factor, IL-1β, ILs, and RANTES in patients with PD, strengthening the clinical evidence that PD is accompanied by an inflammatory response.
Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
TLDR
Results not only strengthen the clinical evidence that neurodegenerative diseases are accompanied by the increased inflammatory response, but also reveal the unique inflammatory response profile in the central nervous system of patients with AD, PD and ALS.
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