A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals

@article{LaluezaFox2007AM1,
  title={A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals},
  author={Carles Lalueza-Fox and Holger R{\"o}mpler and David Caramelli and Claudia St{\"a}ubert and Giulio Catalano and David C Hughes and Nadin Rohland and Elena Pilli and Laura Longo and Silvana Cond{\'e}mi and Marco de la Rasilla and Javier Fortea and Antonio Rosas and M. Stoneking and Torsten Schöneberg and Jaume Bertranpetit and Michael Hofreiter},
  journal={Science},
  year={2007},
  volume={318},
  pages={1453 - 1455}
}
  • Carles Lalueza-Fox, Holger Römpler, +14 authors Michael Hofreiter
  • Published 2007
  • Medicine, Biology
  • Science
  • The melanocortin 1 receptor (MC1R) regulates pigmentation in humans and other vertebrates. Variants of MC1R with reduced function are associated with pale skin color and red hair in humans of primarily European origin. We amplified and sequenced a fragment of the MC1R gene (mc1r) from two Neanderthal remains. Both specimens have a mutation that was not found in ∼3700 modern humans analyzed. Functional analyses show that this variant reduces MC1R activity to a level that alters hair and/or skin… CONTINUE READING

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    Materials and methods are available as supporting material on Science Online

    Ptak for help with the statistical analysis; and the Ministry of Education and Science of Spain and the Generalitat de Catalunya

    • the Deutsche Forschungsgemeinschaft

    We thank C. Green for many suggestions and critical reading of the manuscript