A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

@inproceedings{Jamei2014AMF,
  title={A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine},
  author={Masoud Jamei and Fania Bajot and Sibylle Neuhoff and Zoe E Barter and Jiansong Yang and Amin Rostami-Hodjegan and Karen Rowland-Yeo},
  booktitle={Clinical pharmacokinetics},
  year={2014}
}
BACKGROUND AND OBJECTIVES The interplay between liver metabolising enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion as well as drug attributes including protein and lipid binding, ionisation, relative magnitude of passive and active permeation. Metabolism- and/or transporter-mediated drug-drug interactions (mDDIs and tDDIs) add to the complexity of this interplay. Thus, gaining meaningful insight into the impact of each element on… CONTINUE READING
43 Citations
85 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 85 references

Similar Papers

Loading similar papers…