A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β‐Oxidation

  title={A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid $\beta$‐Oxidation},
  author={C. Hertweck and Andrew P. Jarvis and Li Xiang and Bradley S. Moore and Neil J. Oldham},
The aromatic metabolite benzoic acid (1) is a biosynthetic building block of numerous benzoyl and benzyl groups that serve as important structural elements in a large number of natural products. In eukaryotes, for example, benzoate is a component of the zaragozic acids (2), paclitaxel (taxol ; 3), salicylic acid (4), and cocaine (5) (Figure 1). Although rarer in prokaryotic organisms, benzoyl-coenzyme A (benzoyl-CoA) is a starter unit for a few bacterial polyketides, such as enterocin (6) and… 

Completion of the core β-oxidative pathway of benzoic acid biosynthesis in plants

Discovery of PhCHD completes the elucidation of the core BA β-oxidative route in plants, and together with the previously characterized CoA-ligase and thiolase enzymes, provides evidence that the whole pathway occurs in peroxisomes.

A plant thiolase involved in benzoic acid biosynthesis and volatile benzenoid production.

Using functional genomics, a 3-ketoacyl-CoA thiolase is identified, PhKAT1, which is involved in the benzenoid biosynthetic pathway and the production of BA, which resulted in a major reduction in BA and benzenoids formation in Petunia hybrida.

Characterization of Benzoyl Coenzyme A Biosynthesis Genes in the Enterocin-Producing Bacterium “Streptomyces maritimus”

Experiments provide further support that benzoyl-CoA is formed in a novel bacterial pathway that resembles the eukaryotic assembly of benzoy l coenzyme A from phenylalanine via a beta-oxidative path.

Variations on a theme: synthesis and modification of plant benzoic acids.

  • M. Wildermuth
  • Biology, Chemistry
    Current opinion in plant biology
  • 2006

Engineered Biosynthesis of Phenyl‐Substituted Polyketides

Benzoic acid, activated as its coenzyme A thioester (benzoylCoA) serves as a building block in the biosynthetic pathways to a number of important natural products, including zaragozic acid A


Biotransformations with plant coenzyme A-dependent acyltransferases

To understand the factors that govern substrate selectivity in coenzyme A- dependent acyltransfer, the associated enzymic mechanisms were investigated in vitro and new strategies have been developed to isolate interesting acyl transferase biocatalysts based on their inhibition by a biotinylated fluorophosphonate probe.

The biosynthetic logic of polyketide diversity.

This review highlights recently unveiled biosynthetic mechanisms to generate highly diverse and complex molecules that lead to the large structural diversity of polyketides.

Contribution of CoA Ligases to Benzenoid Biosynthesis in Petunia Flowers[W]

The results indicate that subcellular compartmentalization of enzymes affects their involvement in the benzenoid network and provide evidence that cinnamoyl-CoA formation by Ph-CNL in the peroxisomes is the committed step in the β-oxidative pathway.

Ácido benzoico: biosíntesis, modificación y función en plantas* Benzoic acid: biosynthesis, modification and function in plants

Growing evidence suggests that BA in plants is synthesized directly from the shikimate/chorismate and phenylalanine; however, few genes have been identified in these pathways.