A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid β‐Oxidation

@article{Hertweck2001AMO,
  title={A Mechanism of Benzoic Acid Biosynthesis in Plants and Bacteria that Mirrors Fatty Acid $\beta$‐Oxidation},
  author={C. Hertweck and Andrew P. Jarvis and Li Xiang and Bradley S. Moore and Neil J. Oldham},
  journal={ChemBioChem},
  year={2001},
  volume={2}
}
The aromatic metabolite benzoic acid (1) is a biosynthetic building block of numerous benzoyl and benzyl groups that serve as important structural elements in a large number of natural products. In eukaryotes, for example, benzoate is a component of the zaragozic acids (2), paclitaxel (taxol ; 3), salicylic acid (4), and cocaine (5) (Figure 1). Although rarer in prokaryotic organisms, benzoyl-coenzyme A (benzoyl-CoA) is a starter unit for a few bacterial polyketides, such as enterocin (6) and… 

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