A Mechanism for Zinc Toxicity in Neuroblastoma Cells

  title={A Mechanism for Zinc Toxicity in Neuroblastoma Cells},
  author={Willie M. U. Daniels and Jacobus Hendricks and Ruduwaan Salie and Susan Janse van Rensburg},
  journal={Metabolic Brain Disease},
Zinc is an important component of proteins essential for normal functioning of the brain. However, it has been shown in vitro that this metal, at elevated levels, can be toxic to cells leading to their death. We investigated possible mechanisms of cell death caused by zinc: firstly, generation of reactive oxygen species, and secondly, the activation of the MAP-kinase pathway. Cell viability was assessed by means of the methyl-thiazolyl tetrazolium salt (MTT) assay and confirmed by… CONTINUE READING
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