A Mechanism for Rapacuronium-induced Bronchospasm: M2 Muscarinic Receptor Antagonism

  title={A Mechanism for Rapacuronium-induced Bronchospasm: M2 Muscarinic Receptor Antagonism},
  author={Edmund Jooste and Farrah Klafter and C. Hirshman and C. Emala},
  • Edmund Jooste, Farrah Klafter, +1 author C. Emala
  • Published 2003
  • Medicine
  • Anesthesiology
  • Background A safe and effective ultra-short-acting nondepolarizing neuromuscular blocking agent is required to block nicotinic receptors to facilitate intubation. Rapacuronium, which sought to fulfill these criteria, was withdrawn from clinical use due to a high incidence of bronchospasm resulting in death. Understanding the mechanism by which rapacuronium induces fatal bronchospasm is imperative so that newly synthesized neuromuscular blocking agents that share this mechanism will not be… CONTINUE READING
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