A Mechanism for Rapacuronium-induced Bronchospasm: M2 Muscarinic Receptor Antagonism

@article{Jooste2003AMF,
  title={A Mechanism for Rapacuronium-induced Bronchospasm: M2 Muscarinic Receptor Antagonism},
  author={Edmund Jooste and Farrah Klafter and C. Hirshman and C. Emala},
  journal={Anesthesiology},
  year={2003},
  volume={98},
  pages={906-911}
}
  • Edmund Jooste, Farrah Klafter, +1 author C. Emala
  • Published 2003
  • Medicine
  • Anesthesiology
  • Background A safe and effective ultra-short-acting nondepolarizing neuromuscular blocking agent is required to block nicotinic receptors to facilitate intubation. Rapacuronium, which sought to fulfill these criteria, was withdrawn from clinical use due to a high incidence of bronchospasm resulting in death. Understanding the mechanism by which rapacuronium induces fatal bronchospasm is imperative so that newly synthesized neuromuscular blocking agents that share this mechanism will not be… CONTINUE READING
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    References

    SHOWING 1-10 OF 37 REFERENCES
    Neuromuscular relaxants as antagonists for M2 and M3 muscarinic receptors.
    • 59
    Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung
    • 35
    Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle
    • 100
    Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea‐pig
    • 313
    Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung.
    • 22
    Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.
    • 612