A Mechanism for Coupling Exit from Mitosis to Partitioning of the Nucleus

@article{Bardin2000AMF,
  title={A Mechanism for Coupling Exit from Mitosis to Partitioning of the Nucleus},
  author={Allison J Bardin and Rosella Visintin and Angelika Amon},
  journal={Cell},
  year={2000},
  volume={102},
  pages={21-31}
}
Exit from mitosis must not occur prior to partitioning of chromosomes between daughter cells. We find that the GTP binding protein Tem1, a regulator of mitotic exit, is present on the spindle pole body that migrates into the bud during S phase and mitosis. Tem1's exchange factor, Lte1, localizes to the bud. Thus, Tem1 and Lte1 are present in the same cellular compartment (the bud) only after the nucleus enters the bud during nuclear division. We also find that the presence of Tem1 and Lte1 in… CONTINUE READING
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