A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents

  title={A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents},
  author={Xiaofan Li and Ibukun A. Akinyemi and Jeehyun Karen You and Mohammad Ali Rezaei and Chenglong Li and Michael T. McIntosh and Maurizio Del Poeta and Sumita Bhaduri-McIntosh},
  journal={Journal of Virology},
Epstein-Barr virus, which is nearly ubiquitous in humans, is causal to infectious mononucleosis, chronic active EBV infection, and lymphoid and epithelial cancers. However, EBV-specific antiviral agents are not yet available. To aid in the identification of compounds that may be developed as antivirals, we pursued a mechanism-based approach. Since many of these diseases rely on EBV’s lytic phase, we developed a high-throughput assay that is able to measure a key step that is essential for… 
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