A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents

@article{Li2020AMT,
  title={A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents},
  author={Xiaofan Li and Ibukun A. Akinyemi and Jeehyun Karen You and Mohammad Ali Rezaei and Chenglong Li and Michael T. McIntosh and Maurizio Del Poeta and Sumita Bhaduri-McIntosh},
  journal={Journal of Virology},
  year={2020},
  volume={94}
}
Epstein-Barr virus, which is nearly ubiquitous in humans, is causal to infectious mononucleosis, chronic active EBV infection, and lymphoid and epithelial cancers. However, EBV-specific antiviral agents are not yet available. To aid in the identification of compounds that may be developed as antivirals, we pursued a mechanism-based approach. Since many of these diseases rely on EBV’s lytic phase, we developed a high-throughput assay that is able to measure a key step that is essential for… 
Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency
TLDR
It is found that three structurally distinct prazoles impair maturation of EBV capsids and virion transport from the nucleus, and by interfering with Tsg101, prevent EBV release from lytically-active cells.

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