A Mathematical Model of the Cerebellar-Olivary System I: Self-Regulating Equilibrium of Climbing Fiber Activity

@article{Kenyon1998AMM,
  title={A Mathematical Model of the Cerebellar-Olivary System I: Self-Regulating Equilibrium of Climbing Fiber Activity},
  author={Garrett T. Kenyon and Javier F. Medina and Michael D. Mauk},
  journal={Journal of Computational Neuroscience},
  year={1998},
  volume={5},
  pages={17-33}
}
We use a mathematical model to investigate how climbing fiber-dependent plasticity at granule cell to Purkinje cell (gr→Pkj) synapses in the cerebellar cortex is influenced by the synaptic organization of the cerebellar-olivary system. Based on empirical studies, gr→Pkj synapses are assumed to decrease in strength when active during a climbing fiber input (LTD) and increase in strength when active without a climbing fiber input (LTP). Results suggest that the inhibition of climbing fibers by… CONTINUE READING

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