Corpus ID: 16364694

A Mathematical Model of a Rod Photoreceptor Population

  title={A Mathematical Model of a Rod Photoreceptor Population},
  author={Louis R Joslyn},
Abstract: Phototransduction is a complex biological process in which photons are detected in the retina giving rise to a meaningful representation of incident light. In low-light conditions, this occurs primarily in the rods with the light signal encoded in their membrane potentials. The ionic current model of Kamiyama et al. (1996 and 2009) describes changes in the rod membrane potential due to a photocurrent and other ionic currents. In the retina, rods function together in a large coupled… Expand


Ionic current model of the vertebrate rod photoreceptor
Since the present model describes the biophysical processes from phototransduction to voltage response, the model can be used for analyzing the light response properties of the photoreceptors quantitatively. Expand
Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: Facts and models
The molecular identity and distinct function of the molecules of the transduction cascade in rods and cones are summarized and a mathematical model of the signal-transducing enzymatic cascade is examined, constrained by available electrophysiological, biochemical and biophysical data. Expand
The effect of light on the spread of signals through the rod network of the salamander retina
The effects of light are not completely predicted from computer simulations based on a previous characterization of the properties of isolated rods; these experiments reveal an inadequacy in the description of the rod membrane currents in that model. Expand
Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina
It is found that rod electrical coupling is controlled by a circadian clock and dopamine, and is weak during the day and stronger at night, and the signal‐to‐noise ratio for a dim light response is increased at night because of coupling. Expand
Toward a unified model of vertebrate rod phototransduction.
The model promises to be useful in testing hypotheses regarding both normal and abnormal photoreceptor function, and is a good starting point for development of a full-range model of cone phototransduction. Expand
Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters.
A sensitivity analysis is presented for a self-consistent set of parameters involved in mouse phototransduction, which is found to be very sensitive to variations of the catalytic activities, Hill's coefficients and hydrolysis rates and the geometry of the ROS, including size and shape of the incisures. Expand
Photoreceptor coupling in retina of the toad, Bufo marinus. I. Anatomy.
Red rod photoreceptors in the toad retina were examined for interreceptor contacts and it was concluded that these gap junctions are the site of coupling between the red rods and that the coupling is electrical. Expand
A comprehensive model of the phototransduction cascade in mouse rod cells.
This work presents an adaptation of a previously published, comprehensive model of amphibian phototransduction that can produce quantitatively accurate simulations of the murine photoresponse and demonstrates the ability of the model to predict responses to a wide range of stimuli and under a variety of mutant conditions. Expand
The relation between intercellular coupling and electrical noise in turtle photoreceptors.
1. Intracellular recordings from cones and rods in the retina of the turtle, Pseudemys scripta elegans, revealed that in darkness the cell voltage fluctuated spontaneously about its mean level. TheExpand
Kinetics of phototransduction in retinal rods of the newt Triturus cristatus.
The kinetics of photoresponses to flashes and steps of light of rods, from the retina of the newt Triturus cristatus, were analysed by recording the membrane current with a suction electrode using a model of intracellular calcium buffer. Expand