A Mathematical Model of Immune Activation with a Unified Self-Nonself Concept

@inproceedings{Khailaie2013AMM,
  title={A Mathematical Model of Immune Activation with a Unified Self-Nonself Concept},
  author={Sahamoddin Khailaie and Fariba Bahrami and Mahyar Janahmadi and Pedro Milanez-Almeida and Jochen Huehn and Michael Meyer-Hermann},
  booktitle={Front. Immunol.},
  year={2013}
}
The adaptive immune system reacts against pathogenic nonself, whereas it normally remains tolerant to self. The initiation of an immune response requires a critical antigen(Ag)-stimulation and a critical number of Ag-specific T cells. Autoreactive T cells are not completely deleted by thymic selection and partially present in the periphery of healthy individuals that respond in certain physiological conditions. A number of experimental and theoretical models are based on the concept that… CONTINUE READING
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