A Mathematical Model for the Detection Mechanism of DNA Double-Strand Breaks Depending on Autophosphorylation of ATM

@article{Mouri2009AMM,
  title={A Mathematical Model for the Detection Mechanism of DNA Double-Strand Breaks Depending on Autophosphorylation of ATM},
  author={Kazunari Mouri and Jose C. Nacher and Tatsuya Akutsu},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={895 - 898}
}
BACKGROUND After IR stress, DNA double-strand breaks (DSBs) occur and repair proteins (RPs) bind to them, generating DSB-RP complexes (DSBCs), which results in repaired DSBs (RDSBs). In recent experimental studies, it is suggested that the ATM proteins detect these DNA lesions depending on the autophosphorylation of ATM which exists as a dimer before… CONTINUE READING