A Mammalian Organelle Map by Protein Correlation Profiling

@article{Foster2006AMO,
  title={A Mammalian Organelle Map by Protein Correlation Profiling},
  author={Leonard J. Foster and Carmen L. de Hoog and Yanling Zhang and Yong Zhang and Xiaohui S. Xie and Vamsi K. Mootha and Matthias Mann},
  journal={Cell},
  year={2006},
  volume={125},
  pages={187-199}
}
Protein localization to membrane-enclosed organelles is a central feature of cellular organization. Using protein correlation profiling, we have mapped 1,404 proteins to ten subcellular locations in mouse liver, and these correspond with enzymatic assays, marker protein profiles, and confocal microscopy. These localizations allowed assessment of the specificity in published organellar proteomic inventories and demonstrate multiple locations for 39% of all organellar proteins. Integration of… Expand
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