A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

  title={A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p},
  author={J. Taunton and C. Hassig and S. Schreiber},
  pages={408 - 411}
  • J. Taunton, C. Hassig, S. Schreiber
  • Published 1996
  • Biology, Medicine
  • Science
  • Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar… CONTINUE READING
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