A Malaria Vaccine Based on the Polymorphic Block 2 Region of MSP-1 that Elicits a Broad Serotype-Spanning Immune Response

@inproceedings{Cowan2011AMV,
  title={A Malaria Vaccine Based on the Polymorphic Block 2 Region of MSP-1 that Elicits a Broad Serotype-Spanning Immune Response},
  author={Graeme J. M. Cowan and Alison M. Creasey and Kelwalin Dhanasarnsombut and Alan W. Thomas and Edmond Joseph Remarque and David R. Cavanagh},
  booktitle={PloS one},
  year={2011}
}
Polymorphic parasite antigens are known targets of protective immunity to malaria, but this antigenic variation poses challenges to vaccine development. A synthetic MSP-1 Block 2 construct, based on all polymorphic variants found in natural Plasmodium falciparum isolates has been designed, combined with the relatively conserved Block 1 sequence of MSP-1 and expressed in E.coli. The MSP-1 Hybrid antigen has been produced with high yield by fed-batch fermentation and purified without the aid of… CONTINUE READING
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