A Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection.

@article{Viaud2002AMG,
  title={A Magnaporthe grisea cyclophilin acts as a virulence determinant during plant infection.},
  author={Muriel C Viaud and Pascale V Balhad{\`e}re and Nicholas J. Talbot},
  journal={The Plant cell},
  year={2002},
  volume={14 4},
  pages={917-30}
}
Cyclophilins are peptidyl prolyl cis-trans isomerases that are highly conserved throughout eukaryotes and that are best known for being the cellular target of the immunosuppressive drug cyclosporin A (CsA). The activity of CsA is caused by the drug forming a complex with cyclophilin A and inhibiting the calmodulin-dependent phosphoprotein phosphatase calcineurin. We have investigated the role of CYP1, a cyclophilin-encoding gene in the phytopathogenic fungus Magnaporthe grisea, which is the… CONTINUE READING

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