A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants

@inproceedings{Barnable2014AMA,
  title={A MIV-150/Zinc Acetate Gel Inhibits SHIV-RT Infection in Macaque Vaginal Explants},
  author={Patrick Barnable and Giulia Calenda and Louise A. Ouattara and Agegnehu Gettie and James Blanchard and Ninochka Jean-Pierre and Larisa Kizima and Aixa Rodr{\'i}guez and Ciby J. Abraham and Radhika Menon and Samantha Seidor and Michael L. Cooney and Kevin D. Roberts and Rhoda Sperling and Michael J. Piatak and Jeffrey D Lifson and Jos{\'e} A Fern{\'a}ndez-Romero and Thomas M. Zydowsky and Melissa Robbiani and Natalia Teleshova and Cheryl A Stoddart},
  booktitle={PloS one},
  year={2014}
}
To extend our observations that single or repeated application of a gel containing the NNRTI MIV-150 (M) and zinc acetate dihydrate (ZA) in carrageenan (CG) (MZC) inhibits vaginal transmission of simian/human immunodeficiency virus (SHIV)-RT in macaques, we evaluated safety and anti-SHIV-RT activity of MZC and related gel formulations ex vivo in macaque mucosal explants. In addition, safety was further evaluated in human ectocervical explants. The gels did not induce mucosal toxicity. A single… CONTINUE READING