A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.

@article{Loregger2016AMA,
  title={A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.},
  author={Anke Loregger and Emma C L Cook and Jessica Kristin Nelson and Martina Moeton and Laura Jane Sharpe and Susanna Engberg and Madina Karimova and Gilles Lambert and Andrew J Brown and Noam Zelcer},
  journal={Molecular and cellular biology},
  year={2016},
  volume={36 2},
  pages={285-94}
}
Cholesterol synthesis and lipoprotein uptake are tightly coordinated to ensure that the cellular level of cholesterol is adequately maintained. Hepatic dysregulation of these processes is associated with pathological conditions, most notably cardiovascular disease. Using a genetic approach, we have recently identified the E3 ubiquitin ligase MARCH6 as a regulator of cholesterol biosynthesis, owing to its ability to promote degradation of the rate-limiting enzymes 3-hydroxy-3-methyl-glutaryl… CONTINUE READING
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