A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus*

@article{Bohren2004AMP,
  title={A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus*},
  author={Kurt M. Bohren and Varsha Nadkarni and Jian H. Song and Kenneth H. Gabbay and David Owerbach},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={27233 - 27238}
}
Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance protein stability and activity. We report the identification of a novel intronless SUMO gene, SUMO-4, that encodes a 95-amino acid protein having an 86% amino acid homology with SUMO-2. In contrast to SUMO-2, which is highly expressed in all of the tissues examined, SUMO-4 mRNA was detected mainly in the kidney. A single nucleotide… Expand
Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.
TLDR
Data from this study suggest the contribution of the SUMO4 Met55Val polymorphism to both type 1 and type 2 diabetes susceptibility in the Japanese population. Expand
Analysis of protein SUMOylation and its role in Alzheimer's disease using mouse models
TLDR
It is proved that the newly generated mouse model can be used as a tool for the identification of SUMO3 sub-strates and specifically SU-MO3 from SUMO2, and crossbred His6-HA-SUMO1 knock-in mice with 5xFAD, a mouse model of Alzheimer's disease, to assess SUMO1 conjugation profile in the context of Alzheimer’s disease pathology. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Over‐expression of SUMO‐1 induces the up‐regulation of heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 (hnRNP A2/B1 isoform B1) and uracil DNA glycosylase (UDG) in hepG2 cells
TLDR
It is found that PIASxα, PIasxβ, and PIASy are highly expressed in liver as well as testis by tissue distribution studies and two up‐regulated proteins, heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1 and uracil DNA glycosylase (UDG), have been identified in the EGFP‐SUMO‐1 over‐expressing HepG2 cells. Expand
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