A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid

  title={A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid},
  author={Adrianna Z. Herskovits and Joseph J Locascio and E. R. Peskind and Ge Li and Bradley T. Hyman},
  booktitle={PloS one},
Amyloid beta (aβ) protein assembles into larger protein aggregates during the pathogenesis of Alzheimer's disease (AD) and there is increasing evidence that soluble aβ oligomers are a critical pathologic species. Diagnostic evaluations rely on the measurement of increased tau and decreased aβ42 in the cerebrospinal fluid (CSF) from AD patients and evidence for oligomeric aβ in patient CSF is conflicting. In this study, we have adapted a monoclonal single antibody sandwich ELISA assay to a… CONTINUE READING
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Comparison of Two Analytical Platforms for the Clinical Qualification of Alzheimer’s Disease Biomarkers in PathologicallyConfirmed Dementia

  • N Le Bastard, E Coart, H Vanderstichele, E Vanmechelen, JJ Martin
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  • 2013

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