A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation

@article{Denic2006ALS,
  title={A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation},
  author={Vladimir Denic and Erin M. Quan and Jonathan S. Weissman},
  journal={Cell},
  year={2006},
  volume={126},
  pages={349-359}
}
How the ER-associated degradation (ERAD) machinery accurately identifies terminally misfolded proteins is poorly understood. For luminal ERAD substrates, this recognition depends on their folding and glycosylation status as well as on the conserved ER lectin Yos9p. Here we show that Yos9p is part of a stable complex that organizes key components of ERAD machinery on both sides of the ER membrane, including the transmembrane ubiquitin ligase Hrd1p. We further demonstrate that Yos9p, together… CONTINUE READING
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