A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia

  title={A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia},
  author={William S Yancy and Maren K. Olsen and John R. Guyton and R. P. Bakst and Eric C Westman},
  journal={Annals of Internal Medicine},
Context Low-carbohydrate weight reduction diets are popular despite a dearth of data on long-term efficacy and adverse effects. Contribution Community-dwelling hyperlipidemic persons were randomly assigned to either a low-carbohydrate, ketogenic diet or a low-fat, low-cholesterol, reduced-calorie diet for 24 weeks. Compared to the low-fat group, patients in the low-carbohydrate group lost more weight, had a greater decrease in triglyceride levels, and had higher high-density lipoprotein… 

The effects of low-fat, high-carbohydrate diets on plasma lipoproteins, weight loss, and heart disease risk reduction

Although there is consensus about restriction of dietary saturated and trans fatty acids, cholesterol, and sugars, there is debate about what the optimal total fat and carbohydrate content of the

Effect of a Low-Carbohydrate Diet on Appetite, Blood Glucose Levels, and Insulin Resistance in Obese Patients with Type 2 Diabetes

The effects of a strict low-carbohydrate diet, which included the diet supplements recommended by Dr. Atkins, on energy intake and expenditure, body weight and body water, glucose metabolism, and insulin sensitivity in obese patients with type 2 diabetes in the controlled environment of a clinical research center are determined.

Effects of a Low-carbohydrate, High-fat Diet

It appears that a low-carbohydrate high-fat diet is more effective in weight loss than conventional low-fat diets for short-term periods of approxi-mately 6 months. However, for long-term periods of

Low-Carbohydrate Diets

  • D. Ornish
  • Medicine
    Annals of Internal Medicine
  • 2004
Advocates of a low-carbohydrate diet must prove its efficacy in randomized, controlled trials using direct measures of cardiovascular disease, not just risk factors or epidemiologic studies, especially since diets high in saturated fat and red meat are linked to heart disease, cancer, osteoporosis, and renal disease.

Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

BACKGROUND Trials comparing the effectiveness and safety of weight-loss diets are frequently limited by short follow-up times and high dropout rates. METHODS In this 2-year trial, we randomly

A Low‐carbohydrate Diet Versus a Low‐calorie Diet: Poor Retention

The results suggest that a low-carbohydrate diet may be appropriate for treating overweight and obesity in some adults.

Moderate-carbohydrate low-fat versus low-carbohydrate high-fat meal replacements for weight loss

Both the Low and Moderate Carbohydrate groups lost significantly more weight as well as inches from their waists and thighs than the Control group, while the Low Carbohydrate group lost a greater percentage of body fat.

Low-Carbohydrate High-Fat (LCHF) Diet: Evidence of Its Benefits

This chapter focuses on basic physiology and metabolism of carbohydrate and fat content in normal and diabetic patients and a review of the literature on these two diet combinations with current thoughts and evidence on this core issue affecting insulin utilization and metabolic profile.



A low-carbohydrate as compared with a low-fat diet in severe obesity.

Severely obese subjects with a high prevalence of diabetes or the metabolic syndrome lost more weight during six months on a carbohydrate- restricted diet than on a calorie- and fat-restricted diet, with a relative improvement in insulin sensitivity and triglyceride levels, even after adjustment for the amount of weight lost.

A randomized trial of a low-carbohydrate diet for obesity.

The low-carbohydrate diet produced a greater weight loss than did the conventional diet for the first six months, but the differences were not significant at one year and the low- carbohydrate diet was associated with a greater improvement in some risk factors for coronary heart disease.

Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents.

The LC diet appears to be an effective method for short-term weight loss in overweight adolescents and does not harm the lipid profile.

Postprandial Thermogenesis Is Increased 100% on a High-Protein, Low-Fat Diet versus a High-Carbohydrate, Low-Fat Diet in Healthy, Young Women

Data indicate an added energy-cost associated with high-protein, low-fat diets and may help explain the efficacy of such diets for weight loss.

A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women.

A very low carbohydrate diet is more effective than a low fat diet for short-term weight loss and, over 6 months, is not associated with deleterious effects on important cardiovascular risk factors in healthy women.

Similar weight loss with low- or high-carbohydrate diets.

The results of this study showed that it was energy intake, not nutrient composition, that determined weight loss in response to low-energy diets over a short time period.

Dietary Protein and Weight Reduction

High-protein diets have recently been proposed as a “new” strategy for successful weight loss, but there are no long-term scientific studies to support their overall efficacy and safety and individuals who follow these diets are at risk for compromised vitamin and mineral intake.

Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism

Consumption of an LCHP diet for 6 weeks delivers a marked acid load to the kidney, increases the risk for stone formation, decreases estimated calcium balance, and may increase the risk of bone loss.

Comparative studies in obese subjects fed carbohydrate-restricted and high carbohydrate 1,000-calorie formula diets.

Weight reduction up to day 30 was significantly higher in the subjects on the carbohydrate-restricted diet and there were no significant differences between the water and electrolyte balances.