A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming

@inproceedings{Zhou2018ALO,
  title={A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming},
  author={Yang Zhou and Sahar Alimohamadi and Li Wang and Ziqing Liu and J Blake Joseph Wall and Chaoying Yin and Jiandong Liu and Li Qian},
  booktitle={Stem cells international},
  year={2018}
}
Direct reprogramming of cardiac fibroblasts (CFs) to induced cardiomyocytes (iCMs) is a newly emerged promising approach for cardiac regeneration, disease modeling, and drug discovery. However, its potential has been drastically limited due to the low reprogramming efficiency and largely unknown underlying molecular mechanisms. We have previously screened and identified epigenetic factors related to histone modification during iCM reprogramming. Here, we used shRNAs targeting an additional… CONTINUE READING

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