A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation

@article{Atianand2016ALN,
  title={A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation},
  author={Maninjay K. Atianand and Wenqian Hu and Ansuman T Satpathy and Ying Shen and Emiliano P Ricci and Juan R Alvarez-Dominguez and Ankit Bhatta and Stefan A Schattgen and Jason D. McGowan and Juliana Blin and Joerg E Braun and Pallavi Gandhi and Melissa J. Moore and Howard Y Chang and Harvey F. Lodish and Daniel R. Caffrey and Katherine A. Fitzgerald},
  journal={Cell},
  year={2016},
  volume={165},
  pages={1672-1685}
}
Long intergenic noncoding RNAs (lincRNAs) are important regulators of gene expression. Although lincRNAs are expressed in immune cells, their functions in immunity are largely unexplored. Here, we identify an immunoregulatory lincRNA, lincRNA-EPS, that is precisely regulated in macrophages to control the expression of immune response genes (IRGs). Transcriptome analysis of macrophages from lincRNA-EPS-deficient mice, combined with gain-of-function and rescue experiments, revealed a specific… CONTINUE READING
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