A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

  title={A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads},
  author={Shawn M. Douglas and Ido Bachelet and George M. Church},
  pages={831 - 834}
Nanorobots Deliver DNA aptamers are short strands that have high binding affinity for a target protein that can be used as triggers for releasing cargo from delivery vehicles. Douglas et al. (p. 831) used this strategy to design DNA origami “nanorobots”—complex shaped structures created by manipulating a long DNA strand through binding with shorter “staple” strands—that could deliver payloads such as gold nanoparticles or fluorescently labeled antibody fragments. These nanorobots were designed… 
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  • 2021
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An aptamer-enabled DNA nanobox for protein sensing.
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A tetrahedral DNA nanorobot with conformational change in response to molecular trigger.
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Functional‐DNA‐Driven Dynamic Nanoconstructs for Biomolecule Capture and Drug Delivery
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The DNA origami method is extended into three dimensions by creating an addressable DNA box that can be opened in the presence of externally supplied DNA ‘keys’, and controlled access to the interior compartment of this DNA nanocontainer could yield several interesting applications.
Structure-switching signaling aptamers.
This report describes a strategy for designing aptamer-based fluorescent reporters that function by switching structures from DNA/DNA duplex to DNA/target complex, and reports on the preparation of several structure-switching reporters from two existing DNA aptamers.
Rapid prototyping of 3D DNA-origami shapes with caDNAno
DNA nanotechnology exploits the programmable specificity afforded by base-pairing to produce self-assembling macromolecular objects of custom shape. For building megadalton-scale DNA nanostructures,
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It is shown that chemical reactions with single molecules can be performed and imaged at a local position on a DNA origami scaffold by atomic force microscopy and demonstrate the feasibility of post-assembly chemical modification of DNA nanostructures and their potential use as locally addressable solid supports.
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A strategy for the synthesis of 'nanocrystal molecules', in which discrete numbers of gold nanocrystals are organized into spatially defined structures based on Watson-Crick base-pairing interactions is described.
Precisely Programmed and Robust 2D Streptavidin Nanoarrays by Using Periodical Nanometer‐Scale Wells Embedded in DNA Origami Assembly
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Folding DNA to create nanoscale shapes and patterns
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Selection of aptamers for molecular recognition and characterization of cancer cells.
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