A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo

@inproceedings{Gupta2010ALN,
  title={A Locked Nucleic Acid Antisense Oligonucleotide (LNA) Silences PCSK9 and Enhances LDLR Expression In Vitro and In Vivo},
  author={Nidhi Gupta and Niels Fisker and Marie-Claude Asselin and Marie Lindholm and Christoph Rosenbohm and Henrik \Orum and Joacim Elm{\'e}n and Nabil G Seidah and Ellen Marie Straarup},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates the degradation of hepatic low density lipoprotein receptor (LDLR) and low levels of hepatic PCSK9 activity are associated with reduced levels of circulating LDL-cholesterol. METHODOLOGY/PRINCIPAL FINDINGS The present study presents… CONTINUE READING