A Lissencephaly-1 homologue is essential for mitotic progression in the planarian Schmidtea mediterranea.

Abstract

BACKGROUND Planarians are renowned for their capacity to replace lost tissues from adult pluripotent stem cells (neoblasts). Here we report that Lissencephaly-1 (lis1), which has roles in cellular processes such as mitotic spindle apparatus orientation and in signal regulation required for stem cell self-renewal, is required for stem cell maintenance in the… (More)
DOI: 10.1002/dvdy.23775

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