A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells.

@article{Lin2012ALC,
  title={A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells.},
  author={Yu-Ling Lin and Yen-Ku Liu and Nu-man Tsai and Jui-Hung Hsieh and C-H Chen and Ching-Min Lin and Kuang-Wen Liao},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2012},
  volume={8 3},
  pages={318-27}
}
A cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of hydrophobic curcumin to give curcumin/LPPC. Curcumin/LPPC had an average size less than 270 nm and a zeta potential of approximately 40 mV. The LPPC encapsulation efficiency for curcumin was about 45%. The authors found it surprising that the cytotoxic activity of the curcumin/LPPC was fivefold higher than curcumin when tested on curcumin-sensitive cells and 20-fold more active against curcumin-resistant… CONTINUE READING

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