A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells

@article{Knight2009ALC,
  title={A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells},
  author={Alexandra S. Knight and Maria Notaridou and Roger J. Watson},
  journal={Oncogene},
  year={2009},
  volume={28},
  pages={1737-1747}
}
It has recently been discovered that cell-cycle gene transcription is regulated by a core complex named LINC that switches from a transcriptionally repressive complex in G0–G1 with the p130 or p107 pocket proteins and E2F4 to a transcriptionally active complex in S–G2 containing B-Myb. We have studied the function of LINC in F9 embryonal carcinoma cells, which are distinguished by a rapid cell cycle resulting from an extremely short G1 phase. We show that suppressing expression of the LINC… CONTINUE READING
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E2Fs link the control of G1/S and G2/M transcription.

The EMBO journal • 2004
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