A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

@inproceedings{Walker2010ALN,
  title={A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals},
  author={Laura M Walker and Melissa D. Simek and Frances Priddy and Johannes Simon Gach and Denise Wagner and Michael B. Zwick and Sanjay Kumar Phogat and Pascal Poignard and Dennis R. Burton},
  booktitle={PLoS pathogens},
  year={2010}
}
A protective vaccine against HIV-1 will likely require the elicitation of a broadly neutralizing antibody (bNAb) response. Although the development of an immunogen that elicits such antibodies remains elusive, a proportion of HIV-1 infected individuals evolve broadly neutralizing serum responses over time, demonstrating that the human immune system can recognize and generate NAbs to conserved epitopes on the virus. Understanding the specificities that mediate broad neutralization will provide… CONTINUE READING
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