A Leishmania donovani gene that confers accelerated recovery from stationary phase growth arrest.

  title={A Leishmania donovani gene that confers accelerated recovery from stationary phase growth arrest.},
  author={Cornelia Hoyer and Dorothea Zander and Sandra Fleischer and M. Schilhabel and Manfred Kroener and Mathias Platzer and Joachim Clos},
  journal={International journal for parasitology},
  volume={34 7},
We have isolated a gene, LdGF1, from the protozoan parasite Leishmania donovani. Overexpression of this gene confers a strong selective advantage in liquid culture after stationary phase growth arrest. We could show that recombinant L. donovani or Leishmania major, when overexpressing LdGF1, recover faster from a stationary phase growth arrest than control parasite strains. While no advantage of LdGF1 overexpression could be observed in log phase cultures or after a hydroxyurea-induced S-phase… CONTINUE READING


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