A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

Abstract

NFB is critical in innate immune defense responses against invading microbial pathogens. Legionella pneumophila infection of lung macrophages causes Legionnaire’s disease with pneumonia symptoms. A set of NFB-controlled genes involved in inflammation and anti-apoptosis are up-regulated in macrophages upon L. pneumophila infection in a Legionella Dot/Icm… (More)

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