A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers

@inproceedings{Santa2010ALF,
  title={A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers},
  author={Francesca De Santa and Iros Barozzi and Flore Mietton and Serena Ghisletti and Sara Polletti and Betsabeh Khoramian Tusi and Heiko Muller and Jiannis Ragoussis and Chia-Lin Wei and Gioacchino Natoli},
  booktitle={PLoS biology},
  year={2010}
}
Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are products of RNA genes, however, is still unclear. Here we have characterized transcription sites located outside protein-coding genes in a highly regulated response, macrophage activation by endotoxin… CONTINUE READING
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