A Large Family of Antivirulence Regulators Modulates the Effects of Transcriptional Activators in Gram-negative Pathogenic Bacteria

@inproceedings{Santiago2014ALF,
  title={A Large Family of Antivirulence Regulators Modulates the Effects of Transcriptional Activators in Gram-negative Pathogenic Bacteria},
  author={Araceli E Santiago and Fernando Ru{\'i}z-P{\'e}rez and Noah Y. Jo and Vidhya Vijayakumar and Mei Gong and James P Nataro},
  booktitle={PLoS pathogens},
  year={2014}
}
We have reported that transcription of a hypothetical small open reading frame (orf60) in enteroaggregative E. coli (EAEC) strain 042 is impaired after mutation of aggR, which encodes a global virulence activator. We have also reported that the cryptic orf60 locus was linked to protection against EAEC diarrhea in two epidemiologic studies. Here, we report that the orf60 product acts as a negative regulator of aggR itself. The orf60 protein product lacks homology to known repressors, but… CONTINUE READING

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