A Landmark Protein Essential for Establishing and Perpetuating the Polarity of a Bacterial Cell

@article{Lam2006ALP,
  title={A Landmark Protein Essential for Establishing and Perpetuating the Polarity of a Bacterial Cell},
  author={Hubert Kin Bong Lam and Whitman B. Schofield and Christine Jacobs-Wagner},
  journal={Cell},
  year={2006},
  volume={124},
  pages={1011-1023}
}

Figures and Tables from this paper

A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity
TLDR
This work recapitulate the tripartite assembly of a cell fate signaling complex that forms during the G1-S transition in Caulobacter and demonstrates that the ordered assembly of this microdomain occurs via the polymeric network protein PopZ directly recruiting the polarity factor SpmX, which then recruits the histidine kinase DivJ to the developing cell pole.
A circuit of protein-protein regulatory interactions enables polarity establishment in a bacterium
TLDR
This work has characterized the regulatory interactions between three scaffolding proteins and revealed that the scaffold protein PodJ functions as a central mediator for organizing the new cell signaling hub, including promoting bipolarization of the central developmental scaffolding protein PopZ.
A multimeric pole-organizing protein critical for chromosome attachment , division and protein localization in Caulobacter
TLDR
Evidence is provided that Caulobacter crescentus uses a multimeric pole-organizing factor (PopZ) that serves as a hub to concurrently achieve several polarizing functions and that localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent with a self-organized mechanism.
A multidomain hub anchors the chromosome segregation and chemotactic machinery to the bacterial pole.
TLDR
HubP (hub of the pole), a polar transmembrane protein conserved in all vibrios, is identified that anchors three ParA-like ATPases to the cell poles and, through them, controls polar localization of the chromosome origin, the chemotactic machinery, and the flagellum in Vibrio cholerae.
Cell cycle coordination and regulation of bacterial chromosome segregation dynamics by polarly localized proteins
TLDR
It is shown in Caulobacter crescentus that the polarity factor TipN regulates the directional motion and overall translocation speed of the parS/ParB partition complex by interacting with ParA at the new pole, suggesting a mechanistic framework for adapting a self‐organizing oscillator to create motion suitable for chromosome segregation.
Pole position: How plant cells polarize along the axes
TLDR
This review explores how plant cells coordinately establish stable polarity axes aligned with the organ axes, highlighting similarities in the molecular logic used to polarize both plant and animal cells.
Scaffold-scaffold interactions regulate cell polarity in a bacterium
TLDR
Segregation of PopZ protein at the old pole and recruitment of newly translated PopZ at the new pole via the PodJ scaffold ensures stringent inheritance and maintenance of the polarity axis within dividing C. crescentus cells.
...
...

References

SHOWING 1-10 OF 34 REFERENCES
An actin-like gene can determine cell polarity in bacteria.
TLDR
It is found that the actin-like MreB protein mediates global cellPolarity in Caulobacter crescentus, although the intermediate filament-like CreS protein influences cell shape without affecting cell polarity.
The MreB and Min cytoskeletal‐like systems play independent roles in prokaryotic polar differentiation
TLDR
It is reported that the Min proteins are capable of establishing an axis of oscillation that is the initial step in establishment of polarity in spherical cells, in a process that is independent of the MreB cytoskeleton.
MreB, the cell shape‐determining bacterial actin homologue, co‐ordinates cell wall morphogenesis in Caulobacter crescentus
TLDR
It is hypothesized that MreB filaments function as a cytoskeleton that serves as an organizer or tracking device for the PBP2–peptidoglycan biosynthesis complex.
Presence of Multiple Sites Containing Polar Material in Spherical Escherichia coli Cells That Lack MreB
TLDR
These results are consistent with the requirement, either direct or indirect, for MreB in the restriction of certain polar material to defined sites within the cell and, in the absence of M reB, with the formation of ectopic sites containing polar material.
Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis.
TLDR
It is proposed that polar recruitment of CtrA evolved to ensure that C trA is degraded only in the stalked half of the predivisional cell, perhaps by localizing a proteolytic adaptor protein to the stalking pole.
...
...