A Laminin G-EGF-Laminin G Module in Neurexin IV Is Essential for the Apico-Lateral Localization of Contactin and Organization of Septate Junctions

@inproceedings{Banerjee2011ALG,
  title={A Laminin G-EGF-Laminin G Module in Neurexin IV Is Essential for the Apico-Lateral Localization of Contactin and Organization of Septate Junctions},
  author={Swati Banerjee and Raehum Paik and Rosa E. Mino and Kevin Blauth and Elizabeth S. Fisher and Victoria J Madden and Alan S. Fanning and Manzoor A Bhat},
  booktitle={PloS one},
  year={2011}
}
Septate junctions (SJs) display a unique ultrastructural morphology with ladder-like electron densities that are conserved through evolution. Genetic and molecular analyses have identified a highly conserved core complex of SJ proteins consisting of three cell adhesion molecules Neurexin IV, Contactin, and Neuroglian, which interact with the cytoskeletal FERM domain protein Coracle. How these individual proteins interact to form the septal arrays that create the paracellular barrier is poorly… CONTINUE READING