A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.

@article{Oswald2006ALM,
  title={A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.},
  author={Stefan Oswald and Eberhard Scheuch and Ingolf Cascorbi and Werner Siegmund},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2006},
  volume={830 1},
  pages={143-50}
}
Ezetimibe (Ezetrol) is a novel cholesterol lowering drug which disposition is not fully understood in man. We developed a selective and high-sensitive assay to measure serum concentration-time profiles, renal and fecal elimination of ezetimibe in pharmacokinetic studies. Ezetimibe glucuronide, the major metabolite of ezetimibe was determined by enzymatic degradation to the parent compound. Ezetimibe was measured after extraction with methyl tert-butyl ether using 4-hydroxychalcone as internal… CONTINUE READING

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