A Kunjin replicon vector encoding granulocyte macrophage colony-stimulating factor for intra-tumoral gene therapy

@article{HoangLe2009AKR,
  title={A Kunjin replicon vector encoding granulocyte macrophage colony-stimulating factor for intra-tumoral gene therapy},
  author={Diem Hoang-Le and Leonie Smeenk and Itaru Anraku and Gorben P Pijlman and X J Wang and J de Vrij and Wen Jun Liu and Tiep Le and Wayne A. Schroder and Alexander A Khromykh and Andreas Suhrbier},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={190-199}
}
We have recently developed a non-cytopathic RNA replicon-based viral vector system based on the flavivirus Kunjin. Here, we illustrate the utility of the Kunjin replicon system for gene therapy. Intra-tumoral injections of Kunjin replicon virus-like particles encoding granulocyte colony-stimulating factor were able to cure >50% of established subcutaneous CT26 colon carcinoma and B16-OVA melanomas. Regression of CT26 tumours correlated with the induction of anti-cancer CD8 T cells, and… CONTINUE READING

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