A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons

@article{Solbr2018AKF,
  title={A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons},
  author={A. Solbr{\aa} and A. Bergersen and J. V. D. Brink and A. Malthe-S{\o}renssen and G. Einevoll and G. Halnes},
  journal={PLoS Computational Biology},
  year={2018},
  volume={14}
}
Many pathological conditions, such as seizures, stroke, and spreading depression, are associated with substantial changes in ion concentrations in the extracellular space (ECS) of the brain. An understanding of the mechanisms that govern ECS concentration dynamics may be a prerequisite for understanding such pathologies. To estimate the transport of ions due to electrodiffusive effects, one must keep track of both the ion concentrations and the electric potential simultaneously in the relevant… Expand
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