A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

@inproceedings{Read2013AKR,
  title={A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma},
  author={R. Daniel Read and Tim R. Fenton and G. J. Garc{\'i}a G{\'o}mez and Jill Wykosky and Scott R. Vandenberg and Ivan Babic and Akio Iwanami and Huijun Yang and Webster K Cavenee and Paul Mischel and Frank B Furnari and J Brandon Thomas},
  booktitle={PLoS genetics},
  year={2013}
}
Glioblastoma, the most common primary malignant brain tumor, is incurable with current therapies. Genetic and molecular analyses demonstrate that glioblastomas frequently display mutations that activate receptor tyrosine kinase (RTK) and Pi-3 kinase (PI3K) signaling pathways. In Drosophila melanogaster, activation of RTK and PI3K pathways in glial progenitor cells creates malignant neoplastic glial tumors that display many features of human glioblastoma. In both human and Drosophila, activation… CONTINUE READING
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