A Kinetic Platform to Determine the Fate of Nitric Oxide in Escherichia coli

@inproceedings{Robinson2013AKP,
  title={A Kinetic Platform to Determine the Fate of Nitric Oxide in Escherichia coli},
  author={Jonathan L. Robinson and Mark P. Brynildsen},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Nitric oxide (NO•) is generated by the innate immune response to neutralize pathogens. NO• and its autoxidation products have an extensive biochemical reaction network that includes reactions with iron-sulfur clusters, DNA, and thiols. The fate of NO• inside a pathogen depends on a kinetic competition among its many targets, and is of critical importance to infection outcomes. Due to the complexity of the NO• biochemical network, where many intermediates are short-lived and at extremely low… CONTINUE READING
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